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Entourage Effect: Full-Spectrum Vs. Isolate

Beyond CBD: A Fuller Range Of Benefits

What is the Entourage Effect and why should you choose Full-Spectrum CBD? First off, CBD by itself is pretty awesome. But using only CBD may mean missing out on the full benefits found in real Full-Spectrum CBD.

In this guide, we’ll explain the benefits of Full-Spectrum CBD vs. Isolate CBD and what makes a real Full-Spectrum product. We’ll also explain how you can naturally enhance your CBD experience for the most effective relief.

entourage effect

Why Real Full-Spectrum Matters

There’s over 100 different cannabinoids found in hemp, each with their own unique health benefits!

While CBD & THC are the most common, there’s also cannabinoids like CBDV, CBG, THCV, CBN, CBC, and etc. Each cannabinoid has its own unique benefits which you might not get by only having CBD & THC – which most brands only have in their “full-spectrum” products.

This is why real Full-Spectrum products matter, as they should have the widest range of cannabinoids for us to get the most complete range of health benefits from CBD products.

Compared to a formula with only CBD & THC, a real Full-Spectrum formula with CBD, CBG, CBDV & THCV will have more potential benefits and be more effective for pain, anxiety, sleep or whatever ailment you are hoping to relieve.

What are the benefits of other Cannabinoids?

While CBD can help improve sleep, chronic pain and anxiety, it may not be as effective as other cannabinoids such as a Full-Spectrum formula with CBG, CBDV, or THCV may be for certain ailments.


For Gut Health & Pain

CBG for Gut Health & Pain

CBG may offer powerful antibacterial and anti-inflammatory properties, which could benefit issues such as IBS, colitis and acne. It may also have benefits for those with severe pain and muscle/joint inflammation or arthritis.

buy CBDV skincare epilepsy

For Skincare & Braincare

CBDV for Skincare & Braincare

CBDV may be highly effective as an anti-acne agent and could have powerful neuroprotective effects for those suffering from nausea or epilepsy. CBDV may also have benefits for those suffering from headaches or chronic nerve pain.

more than cbd

THCV For Anti-Anxiety & Focus (Non-Psychoactive)

Anxiety Relief & Focus

THCV is a rare and exclusive cannabinoid that may be a greater anxiety suppressant than CBD, with potential benefits for appetite management and for boosting mental clarity. THCV functions like the exact opposite of THC, actually working to block receptors that respond to THC. THCV is completely non-psychoactive and so it cannot get you high.

Cannabinoids Are Kind of Like Vitamins..

A balanced and healthy diet means having a variety of vitamins and nutrients for the widest range of health benefits. We don’t aim to have just one vitamin or mineral.

A balanced diet also means having a variety of cannabinoids for the greatest range of benefits – which means using a full-spectrum CBD formula. Having multiple cannabinoids together can also create a synergestic “Entourage Effect.”

entourage effect

What is the Entourage Effect?

When you mix CBD, CBG, CBDV, THCV and more together..

When cannabinoids are taken together, they can enhance the effects of each other. This is called the Entourage Effect. Cannabinoids are also enhanced by other plant compounds such as terpenes (smell & flavour compounds found in fruits).

When taken together (like in real Full-Spectrum CBD), Cannabinoids & Terpenes can create a powerful synergestic entourage effect by:

  • Amplifying the effects of each other.
  • Balancing out the negative effects of each other.
  • Making up for what the other is lacking in benefits.

CBD & THC – Balancing Out the Negatives

THC by itself has many benefits, but it’s also linked to negative effects such as increased anxiety, risk of psychosis, increased depression, and of course increased appetite. Long-term use of THC has also been linked to reduced concentration, decreased short-term memory and impaired motor skills.

In nature, THC doesn’t normally occur by itself. Rather, THC usually comes with CBD in wild cannabis & hemp plants. It’s this CBD that helps counteract the negative effects of THC such as anxiety and paranoia – effectively “balancing it out” while still allowing you to have the positive effects of THC’s pain relief. This is a clear case of the entourage effect happening in nature!

THC & THCV – Removing the Negatives & Enhancing the Positives

THCV is a unique and rare cannabinoid that actually has the opposite effects of THC. When combined with THC, THCV can reduce the negatives of THC while enhancing the positives of it.

By using THCV with THC you can reduce the anxiety & hunger of THC, while enhancing the creative energy of THC by boosting your energy & focusdecreasing your appetite, and reducing your anxiety. THCV may also have powerful neuroprotective benefits for Parkinson’s, anti-psychotic effects and promise as an anti-acne agent.

CBD, CBG, CBDV & THCV – Complimenting the Strengths of Each Other

CBD, CBG, CBDV & THCV. Each cannabinoid may be best in one particular area. CBD is all-around great for sleep, pain & anxiety. CBG may be a greater anti-inflammatory than CBD and may be beneficial for IBS/digestive issues. CBDV may be best for skincare & braincare. THCV may be best for boosting your energy, focus and reducing your anxiety. When taken together, having CBD, CBG, CBDV & THCV gives you the perfect overall formula for the most complete range of benefits.

Enhance Your CBD with Fruits & Vegetables!

The Entourage Effect – Synergize With Terpenes

But wait there’s more! In addition to cannabinoids, there are compounds known as terpenes that can enhance the entourage effect of Full-Spectrum CBD.

Where can you find them? They’re right In your kitchen!

Terpenes are the taste and smell compounds in fruits, vegetables and flowers. Terpenes are why lemons taste and smells like lemons, and why strawberries taste and smell like strawberries. Terpenes are naturally produced in plants and may have direct, synergistic benefits when combined with cannabinoids in Full-Spectrum CBD.

entourage effect

Three common household terpenes include caryophyllene, limonene and myrcene.

Caryophyllene is found in herbs and spices like black pepper, basil, oregano and of course in cannabis. It’s that spicey, powerful scent that gives pepper its kick. Caryophyllene has been suggested to have anti-anxiety, anti-inflammatory and antioxidant effects.

Limonene is responsible for the distinct, citrus smell in fruits like lemons, oranges and limes and in cannabis strains like Lemon Haze. Limonene has been suggested to have anti-inflammatory, anti-anxiety, pain-relief, relaxative and antioxidant effects.

Myrcene is responsible for the sweet, tangy smell of fruits like mangoes and nectarines. Myrcene can also be found in plants like bay leaves, hops, lemon grass, basil and rosemary. Myrcene has the synergistic effect of enhancing and strengthening the effect of THC, as it “allows more THC to reach brain cells.” Myrcene has also been suggested to have anti-pain, anti-inflammatory and sleep benefits.

In conclusion, by supplementing your Full-Spectrum CBD with natural foods, you can help boost your Entourage Effect with common terpenes found in your kitchen.

How Can I Experience the Entourage Effect?

Made in BC with all-natural ingredients, our Premium Full-Spectrum Oil Tincture delivers a revolutionary blend of CBD, CBG, CBDV and THCV for the most potent entourage effect for the most complete range of benefits.

Unmatched, Real Full-Spectrum CBD

Other brands simply don’t match our Full-Spectrum Formula, as most only have CBD & THC in their “full-spectrum CBD” vs. CBDNorth’s Full-Spectrum Complex with CBD, CBG, CBDV & THCV.

So if you’re looking to have the most potent entourage effect (that only comes from real Full-Spectrum CBD) our premium oil tincture is the perfect option for you.

Shop Canada’s Best Full-Spectrum.

Shop Canada’s
Best Full-Spectrum.



CBD – (Click for CBD Guide)

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CBG – (Click for CBG Guide)

Couch, D. G., Maudslay, H., Doleman, B., Lund, J. N., & O’Sullivan, S. E. (2018). The use of cannabinoids in colitis: a systematic review and meta-analysis. Inflammatory bowel diseases24(4), 680-697.


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Fernández-Ruiz, J; Moro, M. A; Martínez-Orgado, J (2015). “Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications”. Neurotherapeutics. 12 (4): 793–806. doi:10.1007/s13311-015-0381-7


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Giacoppo, S., Gugliandolo, A., Trubiani, O., Pollastro, F., Grassi, G., Bramanti, P., & Mazzon, E. (2017). Cannabinoid CB2 receptors are involved in the protection of RAW264. 7 macrophages against the oxidative stress: an in vitro study. European journal of histochemistry: EJH61(1).


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THCV – (Click for THCV Guide)

O’brien, L. D., Wills, K. L., Segsworth, B., Dashney, B., Rock, E. M., Limebeer, C. L., & Parker, L. A. (2013). Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability. Pharmacology Biochemistry and Behavior103(3), 597-602.


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Hill, A. J., Williams, C. M., Whalley, B. J., & Stephens, G. J. (2012). Phytocannabinoids as novel therapeutic agents in CNS disorders. Pharmacology & therapeutics133(1), 79-97.


Cascio, M. G., Zamberletti, E., Marini, P., Parolaro, D., & Pertwee, R. G. (2015). The phytocannabinoid, Δ9‐tetrahydrocannabivarin, can act through 5‐HT1A receptors to produce antipsychotic effects. British journal of pharmacology172(5), 1305-1318.


Oláh, A., Markovics, A., Szabó‐Papp, J., Szabó, P. T., Stott, C., Zouboulis, C. C., & Bíró, T. (2016). Differential effectiveness of selected non‐psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment. Experimental dermatology25(9), 701-707.


CBDV – (Click for CBDV Guide)

Amada N, Yamasaki Y, Williams CM, Whalley BJ (2013). “Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression”. PeerJ. 1: e214. doi:10.7717/peerj.214


Iannotti, F. A., Hill, C. L., Leo, A., Alhusaini, A., Soubrane, C., Mazzarella, E., … & Stephens, G. J. (2014). Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. ACS chemical neuroscience5(11), 1131-1141.


Hill, A. J., Mercier, M. S., Hill, T. D. M., Glyn, S. E., Jones, N. A., Yamasaki, Y., … & Williams, C. M. (2012). Cannabidivarin is anticonvulsant in mouse and rat. British journal of pharmacology167(8), 1629-1642.


Rosenberg, E. C., Patra, P. H., & Whalley, B. J. (2017). Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. Epilepsy & Behavior70, 319-327.


Gaston, T. E., & Friedman, D. (2017). Pharmacology of cannabinoids in the treatment of epilepsy. Epilepsy & Behavior70, 313-318.


Hill, T. D. M., Cascio, M. G., Romano, B., Duncan, M., Pertwee, R. G., Williams, C. M., … & Hill, A. J. (2013). Cannabidivarin‐rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor‐independent mechanism. British journal of pharmacology170(3), 679-692.


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Oláh, A., Markovics, A., Szabó‐Papp, J., Szabó, P. T., Stott, C., Zouboulis, C. C., & Bíró, T. (2016). Differential effectiveness of selected non‐psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment. Experimental dermatology25(9), 701-707.


Hill, A. J., Williams, C. M., Whalley, B. J., & Stephens, G. J. (2012). Phytocannabinoids as novel therapeutic agents in CNS disorders. Pharmacology & therapeutics133(1), 79-97.


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